Free sample! camptothecin derivatives with factory price

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US $9.3-20 / Grams | 5 Gram/Grams (Min. Order)
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Overview
Quick Details
Type:
Herbal Extract
Variety:
Camptothecine From Plant extract
Form:
Powder
Part:
Bark
Extraction Type:
Solvent Extraction
Packaging:
Drum
Place of Origin:
Shaanxi, China (Mainland)
Grade:
ISO9001: 2000
Brand Name:
NF
Model Number:
Camptothecine From Plant extract
Camptothecine:
Camptothecine From Plant extract
Molecular Formula:
C20H16N2O4
Molecular weight:
348.36
Test method:
HPLC
Plant original:
Camptotheca acuminata Decne
Specifications:
98%
SupplyAbility
SupplyAbility:
200 Kilogram/Kilograms per Month
Packaging & Delivery
Packaging Details
Foil bag or drum or as your demand
Port
Chinese main port
Lead Time :
Within 1 working day

Product information

 

Product Name: CPT  98% Plant extract  camptothecine

Plant original: Camptotheca acuminata Decne
Specifications: 98% Camptothecine by HPLC
Molecular Formula: C20H16N2O4
Molecular Mass: 348.36


Indications and Uses:
Camptothecin is an alkaloid derived from the Chinese tree Camptotheca acuminata Decne. 

Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, 

by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death. 

In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, 

it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. 

If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein 

cannot be synthesized, it ultimately causes cell death. Application of camptothecin in clinic is limited 

due to serious side effects and poor water-solubility. At present, some camptothecin analogs, either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy 

such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic

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